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KMID : 1234920040040010045
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Journal of Korean Oriental Association for Study of Obesity
2004 Volume.4 No. 1 p.45 ~ p.54
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Effect of Ephedra Sinica and Evodia Rutaecarpa on Resting Metabolic Rate in Obese Premenopausal Women during Low-calorie Diet: A Randomized Controlled Clinical Trial
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Kim Su-Jin
Kim Ho-Jun
Ko Byeong-Pyo
Kim Hyung-Do
Kim Jin-A
Park Jung-Mi
Choi Seung-Ki
Jeon Uoo-Hyun
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Abstract
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Objective: To evaluate the effect of Ephedra Sinica and Evodia Rutaecarpa on resting metabolic rate(RMR), weight and body composition in obese women during low-calorie diet.
Methods: We recruited 90 healthy premenopausal women and randomly assigned to three groups(ephedra group, evodia group and placebo group). Subjects were administered Ephedra Sinica(6g twice a day) or Evodia Rutaecarpa(6g twice a day) or placebo in a double-blind fashion and participated in low-calorie diet for 8 weeks. Resting metabolic rate and body composition were measured at baseline, 4 and 8 weeks.
Results: RMR change for 4 weeks was significantly higher in the ephedra group compared with the placebo group(p<.05). But the change for 8 weeks was not significant and the Evodia group showed no significant RMR change. Weight and percent body fat changes for 4 weeks and 8 weeks were significantly higher than the placebo group in the ephedra group(p<.05), but the Evodia group didn’t show significant level.
Conclusions: This study supports and emphasizes the benefits of herbal medicine in maintaining or increasing RMR during low-calorie diet. Especially Ephedra treatment was effective on significant maintainment of RMR, loss of weight and percent body fat(P<.05).
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KEYWORD
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Ephedra Sinica, Evodia Rutaecarpa, resting metabolic rate, low-calorie diet, obesity, indirect calorimetry
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